Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease |
| |
| Affiliation: | 1. Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;2. Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;3. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;4. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York;5. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York;6. Department of Surgery, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;7. Research Computing, Partners HealthCare, Charlestown, Massachusetts;8. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York;9. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York;10. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;11. Regeneron Genetics Center, Tarrytown, New York;12. Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts;13. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts;14. Stanley Center for Psychiatric Research, Broad Institute, Boston, Massachusetts;15. Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts;p. Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania |
| |
| Abstract: | |
| |
| Keywords: | coronary artery disease genetic risk primary prevention statin ACC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" American College of Cardiology AHA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" American Heart Association ASCVD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" atherosclerotic cardiovascular disease AUROC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" area under the receiver operating characteristic curve CAD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" coronary artery disease CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" confidence interval EHR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" electronic health record FH" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" familial hypercholesterolemia GWAS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" genome-wide association study LDL-C" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" low-density lipoprotein cholesterol OR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" odds ratio PCE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" Pooled Cohort Equations PRS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" polygenic risk score USPSTF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" United States Preventive Services Task Force |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
