免疫调节抗抑郁治疗研究进展

近年来,免疫炎症在抑郁症中的作用受到人们的关注。大量研究表明免疫紊乱在抑郁症的发生中起重要作用,抑郁症患者表现出特征的免疫表型。免疫炎症可以和多种发病机制相互作用介导抑郁症的产生。因此,免疫调节正成为抗抑郁的辅助疗法。在临床治疗中,不仅抗抑郁剂具有抗炎作用,而且抗炎药物也显示出抗抑郁作用,这些药物主要包括非甾体抗炎药、他汀类药物和细胞因子抑制剂。此外,一些非药物治疗方法也具有免疫调节作用,主要有电休克疗法、迷走神经刺激、针灸和运动疗法等。但目前免疫调节治疗仍存在一些问题,如免疫调节治疗只对部分抑郁症亚型有效,且其疗效和安全性还有待评估。因此未来需要寻找更有效的生物标志物,确定免疫炎症相关抑郁症亚型,将有助于探索新的诊疗策略。

Research progress of immune regulation in antidepressant treatment

In recent years,the role of inflammation in depression has received people's attention.Studies have suggested that immune disorder may play an important role in depression,and patients with depression exhibit characteristic immunophenotypes.Inflammation seems to interact with a variety of pathogenesis of depression.Therefore,immunoregulation is becoming an adjuvant therapy for depression.Clinically,not only antidepressants show anti-inflammatory effects,but also anti-inflammatory drugs show antidepressant effects,and they mainly including non-steroidal anti-inflammatory drugs,statins,and cytokine inhibitors.In addition,some non-drug treatment methods are also given immunomodulatory effects,such as electric shock therapy,vagus nerve stimulation,acupuncture and exercise therapy.However,there are still some problems in immunomodulation therapy,such as immunomodulation therapy may be only effective for some subgroups of patients,and its efficacy and safety need to be evaluated.In the future,looking for more effective biomarkers and identifying immune-inflammation-related subtype of depression,will serve to explore new diagnosis and treatment strategies.