Pentraxin 3 level in acute migraine attack with aura: Patient management in the emergency department |
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| Institution: | 1. Health Science University, Gazi Yasargil Research and Training Hospital, Emergency Department, Diyarbak?r, Turkey;2. Health Sciences University, Gazi Yasargil Research and Training Hospital, Biochemistry Department, Diyarbak?r, Turkey;3. Dicle University, School of Medicine, Department of Physiology, Diyarbak?r, Turkey;1. Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;2. Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou, China;3. Weil Institute of Emergency and Critical Care Research, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA;4. Department of Emergency Medicine, The First People''s Hospital of Foshan, 81 Ling Nan Road North, Foshan, Guangdong, 528000, China;1. Department of Urology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;2. Program of Medical Laboratory Techniques, Vocational School of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey;3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey;4. Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;5. Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;6. Department of Urology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkey;7. Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;1. Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel;2. Department of Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel;3. PR, Volunteer Activities, Marketing and International Relations, Magen David Adom, Tel Aviv, Israel |
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| Abstract: | ObjectivesWe investigated the state of inflammation, PTX3 level and other routine inflammatory markers (high sensitivity C-reactive protein hsCRP], and white blood cells WBC]), in patients who presented to the emergency department (ED) with migraine. We also investigated the relationship between the clinical presentation, PTX3 level, and other routine inflammatory markers in the emergency management of these patients.MethodsThe study included 44 patients (group 1) who presented to the ED due to a migraine attack with aura and 44 controls (group 2) with similar demographic characteristics.ResultsThe WBC count was 8.82 ± 2.10 × 109/L in group 1 and 7.85 ± 2.04 × 109/L in group 2. The mean PTX3 level was 11.57 ± 3.99 ng/mL in patients who presented at the ED with a migraine attack, and 4.59 ± 1.28 ng/mL in controls. The differences values of WBC and PTX3 between the two groups were significant (respectively; P = 0.031, P < 0.001). ROC analyses indicated significant results for PTX3 as a marker for acute migraine attack. It had a sensitivity of 93% and specificity of 84% at a cut-off value of 5.80 ng/mL.ConclusionThis is the first study to investigate plasma levels of PTX3 in patients with acute migraine. PTX3 as a biomarker may be used as an additional examination to the current subjective criteria to support the diagnosis of patients presenting to the ED with an acute migraine attack. |
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