| 胎儿生长受限的表观遗传学研究进展 |
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| 引用本文： | 汤秋勤,许倩.胎儿生长受限的表观遗传学研究进展[J].中国优生与遗传杂志,2013(10):9-12,15. |
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| 作者姓名： | 汤秋勤 许倩 |
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| 作者单位： | [1]南京医科大学附属无锡市妇幼保健院产科,无锡214002 [2]南京医科大学第一临床医学院,南京210029 |
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| 摘 要： | 胎儿生长受限是产科重要的特发性疾病之一。近年来研究发现表观遗传变异在胎儿生长受限等妊娠特发性疾病的发生发展中起着重要作用，检测环境暴露和引起胎儿生长相关的表观遗传学改变可为胎儿生长受限的生物学发展和成年后疾病风险度的评估研究提供重要线索。本文就表观遗传学在胎儿生长受限领域的研究现状和进展做一综述，为胎儿生长受限的预防、诊断和治疗提供一种新思路。
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| 关 键 词： | 胎儿生长受限 DNA甲基化 基因组印迹 microRNA |
The epigenetics research progress of fetal growth restriction. |
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| TANG Qiu - qin,XU Qian.The epigenetics research progress of fetal growth restriction.[J].Chinese Journal of Birth Health & Heredity,2013(10):9-12,15. |
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| Authors: | TANG Qiu - qin XU Qian |
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| Institution: | . ( 1. Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, W uxi, 214002; 2. The first clinical medical college of Nanjing Medical University, Nanjing, 210029) |
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| Abstract: | Fetal growth restriction is one of the most important obstetric idiopathic diseases. Recent studies have found that epigenetic variation plays an critical role in the development of fetal growth restriction and other pregnancy idiopathic diseases. Detection of environmental exposure and fetal growth caused epigenetic change would provide important clues for the biological development of fetal growth restriction and adult disease risk assessment research. This article summarizes the current studies on the progress of epigenetics research in the field of fetal growth restriction and provide a new way for fetal growth restriction in prevention, diagnosis and treatment. |
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| Keywords: | Fetal growth restriction DNA methylation Genomic imprinting MicroRNA |
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