| 成体干细胞的横向分化及其可能的机制 |
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| 引用本文： | 陈娟,钱云,刘嘉茵,王彭延. 成体干细胞的横向分化及其可能的机制[J]. 国际生物医学工程杂志, 2004, 27(2): 115-119 |
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| 作者姓名： | 陈娟 钱云 刘嘉茵 王彭延 |
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| 作者单位： | 210029,南京医科大学第一附属医院临床生殖医学中心;300192,天津,中国医学科学院,中国协和医科大学生物医学工程研究所 |
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| 摘 要： | 传统的观点认为成体组织中的干细胞,只能定向分化为其所在组织中的某个或某些特定的细胞,其发育潜能具有限制性。近年来随着研究的深入,许多研究者对这一观点提出了质疑,认为成体干细胞的分化潜能远比先前认为的更为广泛,并将之称为干细胞的横向分化。本文综述了几种成体干细胞的横向分化及其可能的机制。
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| 关 键 词： | 成体干细胞 横向分化 可能的机制 |
| 文章编号： | 1001-1110(2004)02-0115-05 |
| 修稿时间： | 2003-09-04 |
Transdifferentiation of adult stem cells and its possible mechanisms |
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| CHEN Juan,QIAN Yun,LIU Jia-yin . Clinical Reproductive Medicine Center. Transdifferentiation of adult stem cells and its possible mechanisms[J]. International Journal of Biomedical Engineering, 2004, 27(2): 115-119 |
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| Authors: | CHEN Juan QIAN Yun LIU Jia-yin . Clinical Reproductive Medicine Center |
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| Affiliation: | CHEN Juan,QIAN Yun,LIU Jia-yin . Clinical Reproductive Medicine Center,Department of Obstetrics & Gynecology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Traditionally, stem cells in adult tissues were believed to be restricted in their differentiation potential and limited to generate the types of cells present in the tissue in which the stem cell resides. Recently, however, the validity of this understanding has been challenged by evidence that adult stem cells may display a broader differentiation potential, termed transdifferentiation or plasticity, than what was previously thought. In this review, we present some of the evidence for stem cell plasticity and possible explanations for these findings. |
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| Keywords: | adult stem cells transdifferentiation possible mechanisms |
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