呼出气一氧化氮与变应性鼻炎的相关性分析

目的　探讨呼出气一氧化氮（f r a c t io n a l exhaled nitric oxide，FeNO）与变应性鼻炎的相关性。方法　研究66例变应性鼻炎患者视觉模拟量表（visual analogue scale，VAS）评分在治疗前、后与FeNO的相关性。结果　经治疗后FeNO明显下降（t =4.25，P =0.0000），下降比例为（14.56±27.23）%，VAS评分明显下降（t =3.34，P =0.0008），下降比例为（8.68±53.17）%。相关性结果分析，治疗前、后变应性鼻炎患者FeNO与VAS评分具有显著相关性（r =0.43，P =0.0003；r =0.45，P =0.0002）。治疗后变应性鼻炎患者FeNO与VAS评分下降比例具有显著相关性（r =0.25，P =0.0437)。结论　FeNO可以对变应性鼻炎的治疗疗效提供客观的数据依据。

Correlation between fractional exhaled nitric oxide and allergic rhinitis

OBJECTIVETo study the relationship between allergic rhinitis and fractional exhaled nitric oxide (FeNO).METHODS FeNO was measured in 66 allergic rhinitis patients before and after treatment. Visual analogue scale (VAS) score was used to describe the patient's symptoms. RESULTSFeNO and VAS score were significantly decreased after treatment (t=4.25,P=0.0000;t=3.34, P=0.0008), and the decrease proportion were (14.56±27.23)% and (8.68±53.17)% respectively. Correlation analysis showed FeNO and VAS score was significantly correlated before (r=0.43,P=0.0003) and after (r=0.45,P=0.0002) treatment. After treatment, the decreased proportion of FeNO and VAS score were significantly correlated (r=0.25,P=0.0437). CONCLUSIONFeNO can provide objective evidence for the treatment efficacy of allergic rhinitis.