Enhanced spontaneous transmitter release at murine motor nerve terminals with cyclosporine |
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| Authors: | Lin M J Lin-Shiau S Y |
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| Affiliation: | Institute of Pharmacology, National Taiwan University, College of Medicine, Taipei, ROC. |
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| Abstract: | Cyclosporine, a calcineurin inhibitor, significantly enhances spontaneous acetylcholine release after a brief tetanus and potentiates the effect of phorbol 12,13-dibutyrate. Both actions are prevented by the protein kinase C inhibitor, bisindolylmaleimide iodide. Protein kinase C and calcineurin thus play important roles in the balance between phosphorylation and dephosphorylation regulating spontaneous transmitter release at motor nerve terminals. |
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