血管内皮祖细胞与脑血管性疾病

血管内皮祖细胞(EPCs)是成熟血管内皮细胞的前体细胞,也称为成血管细胞,来源于骨髓,可以特异性地归巢于血管新生组织,且分化和增生为成熟内皮细胞的一群干细胞群体。EPCs可以通过特定方式分离,现已发现多种表面标志物,但均缺乏特异性。影响EPCs功能和数量的因素包括内源性因素和外源性因素(如药物、某些疾病和烟酒史等)。随着EPCs的深入研究,已证实EPCs是血管内皮功能的生物学标志,与某些脑血管疾病(如脑卒中、偏头痛和脑白质病变等)有着密不可分的关联。

Endothelial Progenitor Cells and Cerebrovascular Diseases

Endothelial progenitor cells(EPCs)are the precursor cells of mature endothelial cells,also known as vascular cells derived from bone marrow,which can specifically home in angiogenesis tissue,and differentiate and proliferate to mature endothelial cells group.EPCs can be isolated by particular ways,it has been found to have a variety of surface markers,but lack of specificity.The factors of influencing the function and the number of EPCs include endogenous and exogenous(such as drugs,certain diseases,tobacco and alcohol history,etc.).With the research of EPCs deepened,it has been confirmed that EPCs are biological markers of endothelial function,and there is close association between EPCs and cerebral vascular disease(such as stroke,migraine,white matter lesions,etc.).