| Pim-1基因表达与肿瘤相关性的研究进展 |
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| 引用本文： | 丁昭珩. Pim-1基因表达与肿瘤相关性的研究进展[J]. 医学综述, 2012, 18(16): 2584-2586 |
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| 作者姓名： | 丁昭珩 |
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| 作者单位： | 上海交通大学医学院附属新华医院崇明分院肿瘤科,上海,202150 |
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| 摘 要： | 原癌基因Pim-1定位在第6号染色体长臂上(6p21.1～p21.31),其表达产物Pim-1蛋白激酶具有丝氨酸/苏氨酸蛋白激酶活性。Pim-1可抑制细胞凋亡,与肿瘤的发生密切相关。在某些恶性肿瘤中存在Pim-1高表达,虽然Pim激酶家族在细胞增殖、分化、存活方面发挥重要作用,但要阐明Pim-1表达与肿瘤发生的相关性仍需进一步深入研究。
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| 关 键 词： | Pim-1基因 丝/苏氨酸激酶 肿瘤 细胞凋亡 |
Research Progress of the Relationship Between Pim-1 Expression and Tumors |
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| DING Zhao-heng. Research Progress of the Relationship Between Pim-1 Expression and Tumors[J]. Medical Recapitulate, 2012, 18(16): 2584-2586 |
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| Authors: | DING Zhao-heng |
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| Affiliation: | .(Department of Oncology,Chongming Branch of Xinhua Hospital,School of Medi-cine,Shanghai Jiaotong University,Shanghai 202150,China) |
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| Abstract: | Proto-oncogene Pim-1 locates in the long arm of chromosome No.6(6p21.1-p21.31),Pim-1 protein kinase has serine/threonine protein kinase activity.Pim-1 may inhibit apoptosis,and is closely related with tumorigenesis.It is reported that Pim-1 is highly expressed in some malignant tumors.Pim kinase family plays a crucial role in cell proliferation,differentiation and survival,however,further research is still needed to clarify the correlation between Pim-1 expression and tumorigenesis. |
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| Keywords: | Pim-1 gene Serine/threonine kinase Tumor Apoptosis |
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