胱抑素C对早期诊断肝炎后肝硬化患者肾功能损害的临床研究

目的探讨血清胱抑素C(Cys C)检测对早期诊断肝炎后肝硬化患者肾功能损害的意义。方法 38例肝炎后肝硬化患者按照Child-Pugh分级分为三组(A级10例、B级14例、C级14例),另选20例健康者为对照组,测定四组患者的血尿素氮(BUN)、24 h肌酐清除率(Ccr)、血清肌酐(SCr)和血清Cys C水平,并进行比较。结果随着Child-Pugh分级的上升,Ccr逐渐下降,SCr和Cys C逐渐上升(P<0.05);Cys C、SCr均与Ccr有着显著的负相关性(P<0.01),而Cys C的相关系数较高。结论 Cys C能更早期发现肝炎后肝硬化患者肾功能损害,常规监测肝炎后肝硬化患者的Cys C水平,对防治肝肾综合征的发生具有积极意义。

Diagnostic Value of Cystatin C for Early Detection of Renal Injury in Patients with Posthepatitis Cirrhosis

Objective To investigate the diagnostic value of cystatin C(Cys C)for early detection of renal injury in patients with posthepatitis cirrhosis.Methods 38 cases of liver cirrhosis patients according to Child-Pugh classification were divided into three groups(class A 10 cases,class B 14 cases,class C 14 cases);another 20 healthy people were selected as control group,blood urea nitrogen(BUN),24 h creatinine clearance rate(Ccr),serum creatinine(SCr)and serum Cys C levels of the four groups were tested.Results With the rise in Child-Pugh classification,Ccr decreased and SCr and Cys C increased gradually(P<0.05);Cys C and SCr were both significantly inverse correlated with Ccr(P<0.01),while the Cys C correlation coefficient was higher.Conclusion Cystatin C is a more sensitive marker of renal injury in posthepatitis cirrhosis.Routine monitoring of Cys C level in patients with posthepatitis cirrhosis could contribute to the prevention and treatment of hepatorenal syndrome.