阿托伐他汀的临床应用及研究进展

阿托伐他汀属于他汀类调脂药,其主要调脂机制为抑制羟甲基戊二酰辅酶A还原酶,进入体内不需代谢即具有生物活性,具有见效快、作用强、持续时间长等优点。研究发现,除本身的调脂作用外,该药尚具有影响细胞信号转导及细胞增殖、抑制炎性反应、稳定斑块、保护血管内皮功能等多项非调脂功能。现对其近年来临床研究及应用进展予以综述。

Clinical Application and Research Progress of Atorvastatin

As a member of statins,atorvastatin main lipid-lowing mechanism is inhibiting the hydroxymethylglutaryl-CoA reductase.It has biological activities in vivo without metabolism and has many advantages such as fast effects,strong action and long duration.The research shows that,except lipid-lowering effects,atorvastatin can also modulate cell signal transduction and cell proliferation,inhibit inflammation response,stablize plaque,and preserve vascular endothelial function etc..Here is to summarize the recent clinical researches and application progresses of atorvastatin.