176例妊娠合并甲状腺功能异常孕妇妊娠结局分析

目的 分析妊娠合并甲状腺功能异常孕妇妊娠结局.方法 选取我院2012年1月至2014年2月产前筛查甲状腺功能异常的176例孕妇为研究对象,根据筛查结果将其分为甲亢、甲减、亚临床甲减三组,甲减组根据是否干预分为2个亚组;同时选择甲状腺功能正常的100例健康孕妇作为对照组,对所有孕妇的妊娠结局进行观察.结果 甲亢组和甲减干预组的孕妇至妊娠晚期TSH、FT3、FT4均在正常范围内,甲减未干预组和亚临床甲减组TSH明显升高,与甲亢组、甲减干预组和对照组比较差异显著（P＜0.05）.甲亢组和甲减干预组的不良妊娠结局发生率分别为3.45％、4.34％,并发症发生率分别为13.79％、13.04％,明显低于甲减未干预组和亚临床甲减组（P＜0.05）,与对照组相比差异不显著（P＞0.05）.结论 甲状腺功能异常可增加不良妊娠的风险.早期发现和及时有效的干预可降低妊娠风险,获得满意的妊娠结局.

Analysis of Pregnancy Outcome of Pregnancy Complicated with Thyroid Dysfunction with 176 Cases

Objective To analyze the pregnancy outcome of pregnancy complicated with thyroid dysfunction. Methods 176 cases of pregnant women with abnormal thyroid fimction who did prenatal screening in our hospital from January 2012 to February 2014 were selected and randomly divided into hyperthyroidism, hypothyroidism and subclinical hypothyroidism three groups according to the screening results, the hypothyroidism group was divided into two subgroups according to whether giving intervention. 100 cases of healthy pregnant women were selected as control group. The pregnancy outcomes of all pregnant women were observed. Results The TSH, FT3, FT4 of pregnant women in the hyperthyroidism group and hypothyroidism group （implemented intervention） kept in the normal range, the TSH of the hypothyroidism group （not implemented intervention） and subclinical hypothyroidism group was increased significantly, the difference was statistical compared with hyperthyroidism group, hypothyroidism group （implemented intervention） and control group （P 〈0.05）; the incidence of adverse pregnancy outcomes of the hyperthyroidism group and hypothyroidism group （implemented intervention） were 3.45%, 4.34% respectively, the incidence of complications of the two groups was 13.79%, 13.04% respectively, all of these were significantly lower than those of the hypothyroidism group （not implemented intervention） and subclinical hypothyroidism group （P 〈0.05）, and there had no significant statistical difference compared with the control group （P 〉0.05）. Conclusions Thyroid dysfunction can increase the risk of adverse pregnancy, early detection and effective intervention can reduce the risk of pregnancy and get satisfying pregnancy outcomes.