MTRR 66A／G多态性与先天性心脏病易感性的Meta分析

目的探讨MTRR 66A／G多态性与先心病易感性之间的关系。方法全面检索相关文献，收集2013年3月前有关MTRR 66A／G多态性与先心病易感性的病例对照研究和核心家系的连锁不平衡检验研究，使用R软件Catmap软件包进行Meta分析。结果最终纳入8项研究，Meta分析的OR值及95％CI为1.35（95％CI=1.14-1.59，P〈0.001，Pheterogeneity=O.073）。敏感性分析显示所得结果稳定，且按研究方法和种族所进行的分层分析中，除连锁不平衡检验研究亚组外，其余所有亚组OR值均达到显著性水平。结论MTRR 66A／G多态性与先心病易感性之间具有显著关联。

A Meta-Analysis of MTRR 66NG Polymorphism and Congenital heart diseaseI

Objective： To determine whether MTRR 66A/G polymorphism contributes to the risk of Congenital heart disease （CHD） .Methods： Multiple electronic databases were searched to identify studies assessing the relation ship between MTRR 66A/ G polymorphism and Congenital heart disease up to March 2013. To combine case-control and TDT studies, we used the Catmap package of R software to calculate odds ratios （ORs） and 95% confidence intervals （CIs） . Results： A total of 9 reports were included in the final meta-analysis. In overall recta-analysis, the pooled ORs and their 95% confidence intervals were 1.35 （95% CI=1.14-1.59, P〈0.001, Pheterogeneity=0.073） . Sensitivity analyses were carried out to asses the effects of each individual study on the pooled OR, indicating the stability of the outcome. Moreover, positive results were also obtained in all subgroups stratified by study type and ethnicity except the subgroup of TDT studies. Conclusion： The MTRR 66A/G polymorphism might contribute to the susceptibility of Congenital heart disease.