脐血中胰岛素、胰岛素样生长因子-I及胰岛素样生长因子结合蛋白-2与胎儿生长受限的关系

目的探讨脐血中胰岛素、胰岛素样生长因子-I及胰岛素样生长因子结合蛋白-2的水平与胎儿生长受限的关系及意义。方法收集2011年7月～2013年5月在本院分娩的单胎足月正常妊娠（无产科并发症）孕妇及其新生儿各120例，根据出生体重将新生儿分为小于胎龄儿（SGA）组、适于胎龄儿（AGA）2组。胎儿娩出后即抽脐静脉血5ml，标本收集后用高效液相色谱法测定脐血中胰岛素、胰岛素样生长因子-I及胰岛素样生长因子结合蛋白-2的水平。结果SGA组脐带血清胰岛素、胰岛素样生长因子-I水平明显低于AGA组，差异均有统计学意义（P〈0.01）；SGA组脐血胰岛素样生长因子结合蛋白-2水平明显高于AGA、组，差异有统计学意义（P〈0.01）；脐血中胰岛素样生长因子-I与胰岛素水平呈正相关关系，而与胰岛素样生长因子结合蛋白-2呈负相关关系；脐血胰岛素、胰岛素样生长因子-I水平与新生儿出生体重呈正相关关系，而胰岛素样生长因子结合蛋白2与之呈负相关关系。结论脐血胰岛素、胰岛素样生长因子-I、胰岛素样生长因子结合蛋白2与胎儿生长受限的发生密切相关。

The relationship between cord blood levels of insulin,IGF-I,IGFBP-2 and fetal retardation

Objective： To investigate the relationship between cord blood levels of insulin, insulin-like growth factor-I （IGF-I） and insulin-like growth factor binding protein （IGFBP） -2 and fetal retardation. Methods. 120 pregnant women and their newborns were divided into SGA infant and AGA infant according to the birth weight. Umbilical cord blood were collected at birth and the levels of insulin, IGF- I and IGFBP-2 were measured by high performance liquid chromatography. Results： Insulin and IGF- I levels of cord blood in SGA were significantly lower than that of AGA （P〈0.01） ; IGFBP-2 level of cord blood in SGA were significantly higher than that of AGA （P〈0.01） ; Cord blood insulin levels were positively correlated with IGF- I levels;IGFBP-2 level of cord blood was negatively correlated with the levels of insulin and IGF- I ; the levels of cord blood insulin and IGF- I were positively correlated with birth weight, whereas IGFBP-2 had a negative effect on birth weight. Conclusion： Cord blood insulin, IGF- I and IGFBP-2 levels were closely corelated with fetal growth and development.