Revisiting the concept of drug-resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force |
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| Authors: | Stéphane Auvin Aristea S Galanopoulou Solomon L Moshé Heidrun Potschka Luisa Rocha Matthew C Walker the TASK workgroup on drug-resistant epilepsy of the ILAE/AES Joint Translational Task Force |
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| Institution: | 1. Institut Universitaire de France, Paris, France;2. Saul R. Korey Department of Neurology, Isabelle Rapin Division of Child Neurology, Dominick P. Purpura Department of Neuroscience, Albert 3. Einstein College of Medicine, and Montefiore/Einstein Epilepsy Center, Bronx, New York, USA;4. Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany;5. Pharmacobiology Department, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico;6. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK |
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| Abstract: | Despite progress in the development of anti-seizure medications (ASMs), one third of people with epilepsy have drug-resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 2010, helped identify individuals who might benefit from presurgical evaluation early on. As the incidence of DRE remains high, the TASK1 workgroup on DRE of the ILAE/American Epilepsy Society (AES) Joint Translational Task Force discussed the heterogeneity and complexity of its presentation and mechanisms, the confounders in drawing mechanistic insights when testing treatment responses, and barriers in modeling DRE across the lifespan and translating across species. We propose that it is necessary to revisit the current definition of DRE, in order to transform the preclinical and clinical research of mechanisms and biomarkers, to identify novel, effective, precise, pharmacologic treatments, allowing for earlier recognition of drug resistance and individualized therapies. |
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| Keywords: | adult mechanisms model pediatric pharmacoresistance |
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