Preoperative neutrophil-to-lymphocyte ratio is a more valuable prognostic factor than platelet-to-lymphocyte ratio for nonmetastatic rectal cancer |
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| Institution: | 1. Laboratory of Biological Cancer Therapy, Cancer Institute, Xuzhou Medical University, Xuzhou 221002, China;2. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China;3. Department of General Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou 221002, China;1. Department of Rheumatology, Shenzhen Children''s Hospital, Affiliated with Chongqing Medical University, China;2. Department of Rheumatology, Chongqing Children''s Hospital, Affiliated with Chongqing Medical University, China;1. Research Center for Drug Discovery Technology, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea;2. Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea;3. Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 34113 Daejeon, Republic of Korea;4. Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea;1. Department of Urology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, PR China;2. Department of Urology, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, PR China;1. Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi''an, Shaanxi Province, China;2. Department of Trauma, Xi''an Sino-German Orthopaedic Hospital, Xi''an, Shaanxi Province, China;3. Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong Province, China;1. School of Public Health, Shandong University, Jinan 250012, China;2. China Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, China;3. Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130122, China;1. Department of Hematology, Qingdao Central Hospital, the Second Affiliated Hospital, Qingdao University Medical College, Qingdao 266042, China;2. Biotherapy Center, Qingdao Central Hospital, the Second Affiliated Hospital, Qingdao University Medical College, Qingdao 266042, China;3. Department of Hematology, Weifang People''s Hospital, Weifang 261041, China;4. Institute of Hematology, Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 288 Nanjing Road, Tianjin 300060, China |
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| Abstract: | Several combinations of inflammatory factors, including neutrophil-to- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been reported to be prognostic factors in various malignant tumors, including colorectal cancer (CRC). The aim of this study was to evaluate the prognostic value of NLR and PLR for patients with rectal cancer (RC) who underwent curative surgery. Data from patients who underwent curative resection for RC were retrospectively reviewed. The cutoff for NLR and PLR was defined as 2.3 and 144 by receiver operating characteristic (ROC) curve. Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier method. Multivariable Cox regression model was used to evaluate the independent prognostic significance of variables. A total of 140 patients were eligible in the study. High NLR (> 2.3) and high PLR (> 144) both predicted lower OS and DFS according to Kaplan-Meier method. But in the multivariable Cox regression model, only the high NLR retained significance for reduced OS and DFS. According to Chi-square test, patients with higher NLR had larger tumor size and higher pN-stage. While PLR was only associated with the pN-stage. High preoperative NLR was shown to be a negative independent prognostic factor in patients undergoing resection for nonmetastatic RC. It may be helpful as a factor to guide the postoperative therapies. |
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