乙醛脱氢酶1在良恶性腹水鉴别诊断中的价值

目的:通过检测病人腹水乙醛脱氢酶1（ALDH1）的水平，探讨ALDH1在良恶性腹水鉴别诊断上的价值和意义。方法:随机收集恶性腹水32例和良性腹水22例，采用酶联免疫吸附法检测腹水中ALDH1水平，分析ALDH1水平在良恶性腹水中的差异，以及在不同原发疾病中的情况。结果:恶性腹水组年龄较良性腹水组高（P<0.05），但2组间性别分布差异无统计学意义（P>0.05）。良性及恶性腹水组ALDH1水平在不同年龄和性别间差异均无统计学意义（P>0.05）。恶性腹水中ALDH1的水平明显高于良性腹水组（P<0.05）。腹水ALDH1在几种不同原发肿瘤中的水平在肝癌中最高（P<0.05），在消化道癌、子宫内膜癌、卵巢癌、胰腺癌组之间的水平差异均无统计学意义（P>0.05）。良性腹水中肝硬化腹水ALDH1水平较结核性腹膜炎腹水明显升高（P<0.05）。结论:ALDH1在良恶性腹水的鉴别诊断中有重要意义，对临床寻找不明原因腹水的原发疾病具有重要指导意义。

The value of ALDH1 in the differential diagnosis of benign and malignant ascites

Objective:To detect the level of acetaldehyde dehydrogenase 1(ALDH1) of ascites,and explore the value and significance of ALDH1 in differential diagnosis of benign and malignant ascites.Methods:The levels of ALDH1 in 32 malignant ascites cases and 22 benign ascites cases were detected using ELISA.The levels of ALDH1 in benign and malignant ascites,and different primary diseases were analyzed.Results:The age in malignant ascites group was higher than that in benign ascites group(P<0.05),but the difference of the gender distribution between two groups was not statistically significant(P>0.05).The differences of the levels of ALDH1 in two groups among different ages and genders were not statistically significant(P>0.05).The levels of ALDH1 in malignant ascites group was significantly higher than that in benign ascites group(P<0.05).Among few primary tumors,the level of ALDH1 in malignant ascites of liver cancer was the highest,and the differences of the levels of ALDH1 amony digestive tract cancer,endometrial cancer,ovarian cancer and pancreatic cancer were not statistically significant(P>0.05).Among the benign ascites,the level of ALDH1 in liver cirrhosis ascites significantly increased compared with tuberculous peritonitis ascites(P<0.05).Conclusions:ALDH1 has important significance in the differential diagnosis of benign and malignant ascites,and identifying the primary disease of ascites.