血钙水平与冠状动脉病变程度的相关性分析

目的:分析冠状动脉粥样斑块病变的程度与血液中Ca2+含量之间的联系。方法:将冠状动脉造影明确诊断冠状动脉粥样硬化性心脏病病人分为急性心肌梗死（AMI）组、不稳定型心绞痛（UA）组和稳定型心绞痛（ASP）组，选取冠状动脉正常的为对照组。采用SYNTAX评分系统评估冠状动脉病变严程度。结果:ASP组的血Ca2+含量明显小于对照组（P<0.05），AMI组低于UA组、ASP组（P<0.05）。血Ca2+与TG呈正相关关系（P<0.05），与SYNTAX积分呈显著负相关关系（P<0.01）；血液中的K+、Na+、Ca2+含量与EF值均成正相关关系（P<0.05~P<0.01）。血Ca2+含量偏低是导致冠心病的原因之一（P<0.05）。结论:血清中的Ca2+含量越低，冠状动脉粥样斑块的发病率就越高，病变程度就越严重。

Correlation analysis between serum calcium level and severity of coronary artery disease

Objective:To analyze the relationship between the severity of coronary atherosclerotic plaque and serum calcium level.Methods:The patients with coronary atherosclerotic heart disease diagnosed by coronary arteriography were divided into the acute myocardial infarction(AMI) group,unstable angina pectoris group(UA) and stable angina group(ASP),and the normal coronary artery was set as the control group.The severity of coronary artery lesion was assessed using SYNTAX scoring system.Results:The serum calcium content in angina group was significantly lower than that in control group(P<0.05),and the serum calcium level in AMI group was significantly lower than that in UA group and ASP group(P<0.05).The serum calcium level was positive correlation with TG(P<0.05),significantly negative correlation with SYNTAX score.The serum levels of K+,Na+ and Ca2+ were positive correlation with EF value(P<0.05 to P<0.01).The low level of serum calcium is the main one factor of coronary heart disease(P<0.05).Conclusions:The lower the serum calcium content,the higher the incidence rate of coronary atherosclerotic plaques is,and the more serious the lesion is.