Association between airflow limitation and prognosis in patients with chronic pulmonary aspergillosis |
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Authors: | Myoung Kyu Lee Sae Byol Kim Ji-Ho Lee Seok Jeong Lee Sang-Ha Kim Won-Yeon Lee Suk Joong Yong Jong-Han Lee Beomsu Shin |
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Affiliation: | 1.Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;2.Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea |
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Abstract: | BackgroundPrevious studies have shown that reduced levels of lung function, characterized by forced expiratory volume in 1 second (FEV1), are associated with higher respiratory events and mortality in general population and some chronic lung diseases. Chronic pulmonary aspergillosis (CPA) is a destructive, fatal lung disease caused by Aspergillus infection in non-immunocompromised patients with suboptimal pulmonary function. However, there is limited information on the status and features of CPA according to FEV1.MethodsWe performed a retrospective observational study to investigate the FEV1 and airflow limitation in patients with CPA between March 2017 and February 2019 at a tertiary hospital in South Korea.ResultsOf the 144 CPA patients, 104 underwent spirometry, demonstrating median forced vital capacity (FVC) and FEV1 of 2.35 L (68%) and 1.43 L (62%), respectively. Among them, 56 patients had airflow limitation on PFT, with median FVC, and FEV1 of 2.47 L (73%) and 1.11 L (47%), respectively. Low body mass index (BMI) (20.1 vs. 22.1 kg/m2; P=0.011), breathlessness (60% vs. 20%; P=0.002), and bilateral pulmonary lesions (33.3% vs. 4%; P=0.006) were more common in patients with moderate to very severe airflow limitation than in those with normal to mild airflow limitation.ConclusionsModerate to very severe airflow limitation was observed in 43.3% of patients with CPA. Additionally, low BMI, breathlessness, and bilateral pulmonary lesions contributing to poor prognosis were more common in patients with moderate to very severe airflow limitation than in those with normal to mild airflow limitation. Our findings suggest that airflow limitation can be associated with the prognosis of CPA. Further investigations are needed to demonstrate the clinical significance of this association. |
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Keywords: | Pulmonary aspergillosis spirometry pulmonary disease chronic obstructive prognosis |
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