三阴性乳腺癌中CXCL13的表达与临床病理及预后的关系

目的:探讨CXCL13在三阴性乳腺癌（TNBC）中的表达与临床病理特征和预后的关系。方法:收集TNBC组织标本73例和癌旁正常乳腺组织24例。采用免疫组织化学法检测组织中CXCL13蛋白的表达，并分析CXCL13蛋白的表达与临床病理特征和预后的关系。结果:TNBC组织中CXCL13表达显著高于癌旁正常组织（P<0.01）。不同淋巴结转移和临床分期病人CXCL13蛋白的表达差异有统计学意义（P<0.05~P<0.01），有淋巴结转移病人的CXCL13高表达显著高于无淋巴结转移病人（P<0.01）；Ⅰ、Ⅱ期病人的CXCL13高表达者显著低于Ⅲ期病人（P<0.05）。不同年龄、肿瘤大小、绝经情况和肿瘤分化程度CXCL13表达差异无统计学意义（P>0.05）。CXCL13高表达病人的5年生存率为49.1%，低于低表达病人的82.9%（χ2=6.49，P<0.05）。结论:CXCL13与TNBC的进展有关，CXCL13可以作为TNBC的独立预后因素。

Expression of CXCL13 in triple-negative breast cancer and its correlation with clinical pathology and prognosis

Objective:To explore the expression of CXCL13 in triple-negative breast cancer(TNBC),and its correlation with clinical pathology and prognosis.Methods:The expression levels of CXCL13 in 73 TNBC tissue samples and 24 paracancerous normal breast tissue samples were detected using immunohistochemical staining,and the correlation of the CXCL13 expression levels with clinical pathology and prognosis was analyzed.Results:The expression level of CXCL13 in TNBC tissue was higher than that in paracancerous normal breast tissue(P<0.01),the differences of the CXCL13 expression in different node metastasis and clinical stages were statistically significant(P<0.05 to P<0.01),the CXCL13 expression in patients with node metastasis was significantly higher than that in patients without node metastasis(P<0.01),and the CXCL13 expression level in stage Ⅰ/Ⅱ patients was significantly lower than that in stage Ⅲ patients(P<0.05).The differences of CXCL13 expression levels in different age,tumor size,menopausal status and differentiation degree of tumor were not statistically significant(P>0.05).The five-year survival rate in patients with high CXCL13 expression(49.1%) was lower than that in patients with low CXCL13 expression(82.9%)(χ2=6.49,P<0.05).Conclusions:The CXCL13 expression is related to the progress of TNBC,and CXCL13 may be an independent prognosis factor for TNBC.