Ghrelin与心房颤动的相关性研究

目的:探讨心房颤动（AF）病人血清Ghrelin水平与疾病进展的关系。方法:用ELISA方法对80例持续性AF病人和80例窦性心律不齐病人的血清Ghrelin水平进行检测，且测定所有病例血糖、血脂、肝肾功能和超声心动图。AF病人进行8周的常规治疗后再重新测定所有指标。结果:AF组血清Ghrelin水平明显低于窦性心律失常组（P<0.01）；AF组病人血清Ghrelin水平与LVEF呈正相关（r=0.698，P<0.05）。治疗后，AF组病人的血清Ghrelin水平和LVEF显著升高，而LAD降低（P<0.05）。结论:AF组病人血清Ghrelin水平与LVEF呈正相关，定期检查Ghrelin水平有助于诊断AF的进展。

Study on the relationship between Ghrelin expression and atrial fibrillation

Objective:To investigate the relationship between the serum level of Ghrelin and progression of atrial fibrillation(AF).Methods:The serum levels of Ghrelin in 80 patients with persistent AF(AF group) and 80 patients with sinus arrhythmia(SA)(SA group) were tested using ELISA.The blood glucose,lipid,liver and kidney function,and echocardiography in two groups were measured.All indexes in AF patients were detected after 8 weeks of conventional treatment.Results:The serum level of Ghrelin in AF group was significantly lower than that in SA group(P<0.01).The serum level of Ghrelin was positively correlated with LVEF in AF group(r=0.698,P<0.05).After treatment,the serum levels of Ghrelin and LVEF significantly increased,and the LAD level decreased in AF group.Conclusions:The serum level of Ghrelin is positively correlated with LVEF in patients with AF,regular examination of Ghrelin levels contributes to the progress of AF diagnosis.