Senescent endothelial cells: Potential modulators of immunosenescence and ageing |
| |
| Affiliation: | 1. Department of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka Street 6/8, Lodz 92-215, Poland;2. Department of Immunology, Institute of Medical Biotechnology, Tbilisi State Medical University, Chiaureli Street 2a, Tbilisi 0159, Georgia;1. VIB-Center for Cancer Biology, and KU Leuven, Department of Oncology, 3000 Leuven, Belgium;2. Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA;1. Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China;2. Department of Medicine and Veterans Affairs Puget Sound Health Care Systems (VAPSHCS), University of Washington, Seattle, WA 98195, USA;3. Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA;4. Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK;1. Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, 00133 Rome, Italy;2. Biochemistry Laboratory, Istituto Dermopatico dell’Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Rome, Italy;3. Medical Research Council, Toxicology Unit, Leicester University, Hodgkin Building, Lancaster Road, P.O. Box 138, Leicester LE1 9HN, UK;4. Department of Pathobiology and Medical Biotechnologies, University of Palermo, 90134 Palermo, Italy;5. Department of Systems Medicine, Hypertension and Nephrology Unit, University of ‘Tor Vergata’, Rome, Italy;1. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China;2. Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China;3. College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China |
| |
| Abstract: | Recent studies have demonstrated that the accumulation of senescent endothelial cells may be the primary cause of cardiovascular diseases. Because of their multifunctional properties, endothelial cells actively take part in stimulating the immune system and inflammation. In addition, ageing is characterized by the progressive deterioration of immune cells and a decline in the activation of the immune response. This results in a loss of the primary function of the immune system, which is eliminating damaged/senescent cells and neutralizing potential sources of harmful inflammatory reactions.In this review, we discuss cellular senescence and the senescence-associated secretory phenotype (SASP) of endothelial cells and summarize the link between endothelial cells and immunosenescence. We describe the possibility that age-related changes in Toll-like receptors (TLRs) and microRNAs can affect the phenotypes of senescent endothelial cells and immune cells via a negative feedback loop aimed at restraining the excessive pro-inflammatory response. This review also addresses the following questions: how do senescent endothelial cells influence ageing or age-related changes in the inflammatory burden; what is the connection between ECs and immunosenescence, and what are the crucial hypothetical pathways linking endothelial cells and the immune system during ageing. |
| |
| Keywords: | Endothelial cells Immunosenescence SASP Ageing |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
