Molecular characterization of the first G24P[14] rotavirus strain detected in humans |
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| Affiliation: | 1. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;2. Texas Children''s Hospital, Houston, TX, USA;3. Baylor College of Medicine, Houston, TX, USA;1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Environmental Protection Research Institute of Light industry, Beijing 100089, China;4. School of Chemical & Environmental Engineering, China University of Mining & Technology (Beijing), Beijing 100083, China;5. Institute of Environment and Health, Jianghan University, Wuhan 430056, China |
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| Abstract: | Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans. |
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