Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence |
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| Affiliation: | 1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia;2. Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia;3. Centre for Infectious Diseases and Microbiology–Public Health, Institute of Clinical Pathology and Medical Research–Pathology West, Westmead Hospital, New South Wales, Australia;4. Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, New South Wales, Australia;5. National Centre for Immunisation Research and Surveillance, Children''s Hospital at Westmead and University of Sydney, New South Wales, Australia;6. Vaccinology and Immunology Research Trials Unit, Women''s and Children''s Hospital and School of Paediatrics and Reproductive Health and Robinson Research Institute, University of Adelaide, South Australia, Australia;1. Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia;2. Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Australia;3. School of Mathematics and Statistics, The University of Melbourne, Parkville, Australia;4. National Centre for Immunisation Research and Surveillance, The Children''s Hospital at Westmead, Westmead, Australia;1. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK;2. Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA;1. Institut Pasteur, Paris, France;2. Meade Biologics LLC, Hillsborough, NC, USA;3. Formerly Helios Klinikum Krefeld, Krefeld, Germany;1. Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD 20993, USA;2. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;3. Vanderbilt Vaccine Research Program, Vanderbilt University, 21st Avenue South, S 2323 MCN, Nashville, TN 37232, USA |
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| Abstract: | Whooping cough, or pertussis, is resurgent in many countries world-wide. This is linked to switching from the use of whole cell vaccines to acellular vaccines in developed countries. Current evidence suggests that this has resulted in the earlier waning of vaccine-induced immunity, an increase in asymptomatic infection with concomitant increases in transmission and increased selection pressure for Bordetella pertussis variants that are better able to evade vaccine-mediated immunity than older isolates. This review discusses recent findings in B. pertussis epidemiology and evolution in the light of pertussis resurgence, and highlights the important role for genomics-based studies in monitoring B. pertussis adaptation. |
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