Blunted reward responsiveness in remitted depression |
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| Affiliation: | 1. McLean Hospital & Harvard Medical School, USA;2. Yale University, USA;3. Duke University, USA;1. The Corporal Michael J. Crescenz VA Medical Center, United States;2. University of Pennsylvania, United States;1. Department of Psychology & Neuroscience, Duke University, Durham, NC 27710, USA;2. Program on Integrative Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;3. Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;4. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA;5. UNC Neurobiology Curriculum, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;6. Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA;7. Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;1. School of Psychiatry, University of New South Wales, NSW, Australia;2. Black Dog Institute, NSW, Australia;3. Centre for Psychological and Relationship Counselling, VIC, Australia;4. Massachusetts General Hospital, Boston, MA, USA;5. Harvard Medical School, Boston, MA, USA;6. The Mount Sinai Hospital, New York, NY, USA;7. McLean Hospital, Belmont, MA, USA;1. Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA;2. Department of Psychiatry, Harvard Medical School, MA, USA;3. Department of Psychology, Harvard University, Cambridge, MA, USA;4. McLean Imaging Center, McLean Hospital, Belmont, MA, USA;5. Department of Psychology, Yale University, New Haven, CT, USA;6. Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA;1. Department of Psychology, Stony Brook University, Stony Brook, NY 11794, USA;2. Emotion and Development Branch, National Institute of Mental Health (NIMH), Bethesda, MD 20892, USA;3. Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63130, USA;4. Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130, USA;5. Department of Radiology, Washington University in St. Louis, St. Louis, MO 63130, USA;6. Neuroscience Program, Washington University in St. Louis, St. Louis, MO 63130, USA;1. Department of Psychiatry, University of California San Diego, La Jolla, California;2. Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts |
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| Abstract: | Major depressive disorder has been associated with blunted responsiveness to rewards, but inconsistencies exist whether such abnormalities persist after complete remission. To address this issue, across two independent studies, 47 adults with remitted major depressive disorder (rMDD) and 37 healthy controls completed a Probabilistic Reward Task, which used a differential reinforcement schedule of social or monetary feedback to examine reward responsiveness (i.e., ability to modulate behavior as a function of reinforcement history). Relative to controls, adults with rMDD showed blunted reward responsiveness. Importantly, a history of depression predicted reduced reward learning above and beyond residual depressive (including anhedonic) symptoms and perceived stress. Findings indicate that blunted reward responsiveness endures even when adults are in remission and might be a trait-related abnormality in MDD. More research is warranted to investigate if blunted reward responsiveness may predict future depressive episodes and whether targeting reward-related deficits may prevent the re-occurrence of the disorder. |
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| Keywords: | Reward Positive reinforcement Major depressive disorder |
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