Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma |
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Authors: | Zhengjun Zhou Junjie Tian Wenyan Zhang Wei Xiang Yang Ming Ligang Chen Jie Zhou |
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Affiliation: | 1.Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China;2.Sichuan Clinical Research Center for Neurosurgery, Luzhou, Sichuan 646000, P.R. China;3.Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan 646000, P.R. China;4.Neurological Diseases and Brain Function Laboratory, Luzhou, Sichuan 646000, P.R. China |
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Abstract: | Oncolytic viruses have attracted widespread attention as biological anticancer agents that can selectively kill tumor cells without affecting normal cells. Although progress has been made in therapeutic strategies, the prognosis of patients with glioblastoma (GBM) remains poor and no ideal treatment approach has been developed. Recently, oncolytic herpes simplex virus (oHSV) has been considered a promising novel treatment approach for GBM. However, the therapeutic efficacy of oHSV in GBM, with its intricate pathophysiology, remains unsatisfactory due to several obstacles, such as limited replication and attenuated potency of oHSV owing to deletions or mutations in virulence genes, and ineffective delivery of the therapeutic virus. Multiple strategies have attempted to identify the optimal strategy for the successful clinical application of oHSV. Several preclinical trials have demonstrated that engineering novel oHSVs, developing combination therapies and improving methods for delivering oHSV to tumor cells seem to hold promise for improving the efficacy of this virotherapy. |
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Keywords: | glioblastoma oncolytic herpes simplex virus armed virus antiviral immunity combination therapy |
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