乙型肝炎病毒e抗体检测在原发性肝癌中的临床意义

本文报告119例PHC和非肝脏恶性肿瘤和肝良性占位变82例血清HBV感染结果。表明在PH-C和其他疾病的HBV感染标志的阳性率分别是:e抗体60.5％和24.4％,HBsAg63.0％和17.1％,抗HBc为78.2％和24.4％,抗HBs 5％和14.6％,HBeAg11.8％和8.5％,HBV总暴露率91.6％和32.9％,其中e抗体,抗HBc,HBV总暴露率PHC组显著地高于对照组。抗HBs则相反。资料表明e抗体阳性率随病情的进展,肿块的增大而增高。提示e抗体的存在与癌细胞的增殖,肝细胞的癌变有关。它作为HBV感染标志之一应予重视。

Detection of HBV Markers in Patients with Primary Hepatic Carcinoma

HBV markers were determined in the sera from 119 cases of PHC, 48 cases of other cancers including lung, stomach, colon, rectum and breast carcinoma, and 34 benign hepatic lesions including abscess, cyst and hemangioma. The positive rates of HBV markers in PHC group vs control group (consisted of patients with other cancers and hepatic benign lesions) were as the following: anti-HB_ 60.5 vs 24.4%, HBs Ag 63.0 vs 17.1%, anti-HBe 78.2 vs 24.4%, anti-HBs 5 vs 14.6%, HBeAg 11.8 vs 8.5% and HBV exposure rates 91.6 vs 32.9%. The positive rates ot anti-HBe, antiHBc and HBsAg, as well as HBV exposure rate in PHC group were significantlyhigher than those in control group. It was found that the positive rate of anti-HBe was increased with progression of the disease and growth of tumor mass. The evidence indicated that the level of anti-HBe in PHC mi^ht be probably related to the proliferation of cancer cells.