| 枸杞多糖对染铅小鼠学习记忆及海马区PKC影响 |
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| 引用本文： | 蔡天革,蔡宇,余绍蕾.枸杞多糖对染铅小鼠学习记忆及海马区PKC影响[J].中国公共卫生,2010,26(1). |
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| 作者姓名： | 蔡天革 蔡宇 余绍蕾 |
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| 作者单位： | 1. 辽宁大学生命科学学院,沈阳,110036
2. 暨南大学药学院 |
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| 摘 要： | 目的探讨枸杞多糖对染铅小鼠学习记忆功能和海马区蛋白激酶C(Protein kinase C,PKC)的影响。方法将实验小鼠随机分为5组,即空白对照组、染铅模型组、枸杞多糖高、中、低3个剂量组,枸杞多糖各剂量组于染铅后第2d灌胃给药,每天1次,于第2,4周测小鼠到达迷宫避难台所需要的时间,第4周测血铅浓度和海马区PKC含量。结果枸杞多糖各剂量组与染铅模型组比较,血铅浓度枸杞多糖各剂量组(0.65±0.28)～(0.11±0.13)mg/L,模型组(1.68±0.19)mg/L]明显降低,到达避难台的时间也明显减少;而海马区PKC含量枸杞多糖各剂量组(73.23±6.52)～(96.33±8.03)mmol/L,模型组(62.26±7.21)mmol/L]明显升高,差异有统计学意义(P0.05或P0.01)。结论枸杞多糖可促进小鼠体内铅的排出,改善染铅小鼠的学习记忆功能,抑制海马区PKC含量降低。
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| 关 键 词： | 枸杞多糖 铅 海马区 蛋白激酶C |
Influenec of Lycium barbarum polyccharides on learning and menory function and protein kinase C in hippocampus in lead-exposed mice |
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| CAI Tian-ge,CAI Yu,YU Shao-lei.Influenec of Lycium barbarum polyccharides on learning and menory function and protein kinase C in hippocampus in lead-exposed mice[J].Chinese Journal of Public Health,2010,26(1). |
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| Authors: | CAI Tian-ge CAI Yu YU Shao-lei |
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| Institution: | CAI Tian-ge,CAI Yu,YU Shao-lei. College of Life Science,Liaoning University(Shenyang 110036,China) |
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| Abstract: | Objective To explore the influence of Lycium barbarum polyccharides(LBP)on learning and memory function and the content of protein kinase C(PKC)in hippocampus of lead-exposed mice.Methods The mice were divided randomly into five groups:control group,lead-exposed model group,high-,mid-and low-dosage LBP groups.The LBP groups were fed with different dosage of LBP since the second day of the lead exposure.Blood-lead concentration,time of reaching water maze platform at 2nd and 4th week,and the concentration of... |
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| Keywords: | Lycium barbarum polyccharides (LBP) lead hippocampus PKC |
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