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Development of human striatal anlagen after transplantation in a patient with Huntington's disease |
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| Authors: | Gallina Pasquale Paganini Marco Lombardini Letizia Saccardi Riccardo Marini Mirca De Cristofaro Maria Teresa Pinzani Pamela Salvianti Francesca Crescioli Clara Di Rita Andrea Bucciantini Sandra Mechi Claudia Sarchielli Erica Moretti Marco Piacentini Silvia Gritti Gaetano Bosi Alberto Sorbi Sandro Orlandini Giovanni Vannelli Gabriella B Di Lorenzo Nicola |
| Affiliation: | a Department of Neurosurgery, University of Florence, Florence, Italy b Department of Neurology, University of Florence, Florence, Italy c Department of Haematology, University of Florence, Florence, Italy d Department of Neuroimaging, University of Florence, Florence, Italy e Department of Anatomy, University of Florence, Florence, Italy f Department of Clinical Physiopathology, University of Florence, Florence, Italy g Department of Anesthesiology, University of Florence, Florence, Italy |
| Abstract: | Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first “in vivo” demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma. |
| Keywords: | Neurotransplantation Fetal striatal tissue Huntington's disease Neuroblasts Restoration |
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