| 中药逆转乳腺癌细胞多药耐药性的实验研究 |
| |
| 引用本文： | 谭成,俞惠新,林秀峰,陈波,张荣军,蔡刚明,肖晔,曹国宪. 中药逆转乳腺癌细胞多药耐药性的实验研究[J]. 中药药理与临床, 2005, 21(3): 32-34 |
| |
| 作者姓名： | 谭成 俞惠新 林秀峰 陈波 张荣军 蔡刚明 肖晔 曹国宪 |
| |
| 作者单位： | 江苏省原子医学研究所,无锡,214063 |
| |
| 基金项目： | 江苏省中医药管理局科研项目，江苏省科技厅社会发展基金 |
| |
| 摘 要： | 目的:从单味中药中筛选具有逆转乳腺癌细胞耐药性的逆转剂.方法:建立乳腺癌耐药细胞的细胞模型,采用SRB法测定单味中药及其对应血清的细胞毒性作用及其逆转作用.结果:理气类中药中延胡索具有对MCF-7/VCR耐药性的逆转作用,而且它的细胞毒作用很小;1.667g/L的延胡索可使MCF-7/VCR的耐药性逆转3.27倍.结论:延胡索能够有效地逆转乳腺癌细胞MCF-7/VCR的耐药性.
|
| 关 键 词： | 延胡索 多药耐药 乳腺癌 |
An experimental study on Chinese traditional medicine reverse the mammary carcinoma cell resistance |
| |
| TAN Cheng,YU Huixin,Lin Xiufeng,Chen Bo,Zhang Rongjun,CAI Gangming,Xiao Ye,CAO Guoxian. An experimental study on Chinese traditional medicine reverse the mammary carcinoma cell resistance[J]. Pharmacology and Clinics of Chinese Materia Medica, 2005, 21(3): 32-34 |
| |
| Authors: | TAN Cheng YU Huixin Lin Xiufeng Chen Bo Zhang Rongjun CAI Gangming Xiao Ye CAO Guoxian |
| |
| Abstract: | Objective: To screen new drugs which can reverse the multidrug resistance (MDR) of mammary carcinoma cell MCF-7 from a large amounts of Chinese traditional medicine. Methods: We establish a cellular model of mammary carcinoma with MDR. The cytotoxicity and reverse effects of Chinese traditional medicine and their corresponding serums are identified using SRB assay. Results: Yanhusuo can reverse the resistance of MCF-7/VCR and its cytotoxicity is minimal. At the concentration of 1.667g/L, the reverse effects of yanhusuo on the multidrug resistance of MCF-7/VCR is 3.27 fold. Conclusion: Yanhusuo can efficiently reverse the resistance of MCF-7/VCR. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
