Pharmacological analysis of the activity of phenazepam and flunitrazepam administered in superlow doses |
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| Authors: | G M Molodavkin E B Burlakova L I Chernyavskaya T A Voronina N I Khorseva S B Seredenin |
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| Institution: | (1) Institute of Chemical Physics, Russian Academy of Sciences, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Benzodiazepine tranquilizers, phenazepam and flunitrazepam, administered to random-bred albino male rats in superlow doses
(10−9–10−15 mol/kg), are shown to exert an anxiolytic effect in the conflict test. In contrast to the case with the usual doses, the
above effect is not accompanied by marked myorelaxant or sedative effects.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 164–166, February, 1996 |
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| Keywords: | tranquilizers anxiolytic activity superlow doses |
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