正交试验优选复方桑菊口服液中药材的提取工艺

目的:优选复方桑菊口服液中药材的提取工艺。方法:以加水量、浸泡时间、提取时间、提取次数为考察因素,以连翘苷提取量、绿原酸提取量及干膏得率为评价指标,采用正交试验优选桑叶、野菊花、连翘、甘草、桔梗、芦根、苦杏仁的水提取工艺;以浸泡时间、超声时间、提取时间、加水量为考察因素,以挥发油得率为评价指标,采用正交试验优选薄荷叶的水蒸气蒸馏提取工艺。结果:优选的水提取工艺为加8倍量的水,浸泡2 h,提取2次,每次1.5 h;薄荷叶的提取工艺为加10倍量的水,浸泡1 h,超声处理60 min,提取4 h。结论:所选工艺合理、可行,可用于复方桑菊口服液中药材的提取。

Optimization of Extraction Technology of Chinese Medicinal Materials from Compound Sangju Oral Liquid

OBJECTIVE： To optimize the extraction technology of Chinese medicinal materials from Compound sangju oral liq- uid. METHODS： The water extraction technologies of Morus alba, Chrysanthemum indicum, Forsythia suspense, Glycyrrhizaura uralensis, Platycodon grandiflorum, Phragmites communis, Semen Armeniacae Arnarum were optimized by orthogonal experiment with amount of water, soaking time, extraction time and extraction times as factor using the extraction volume of phillyrin and chlorogenic acid, the yield of extract as index. The extraction technology of Mentha haplocalyx was optimized by orthogonal experiment with soaking time, ultrasonic processing time, extraction time and amount of water as factors using the yield of volatile oil as index. RESULTS ： Optimal water extraction technology was as follows： 8 folds of water, soaking for 2 h, extracting for 2 times, 1.5 h each time. The extraction technology of M. haplocalyx was as follows： 10 folds of water, soaking for 1 h, ultrasonic processing time of 60 min, extracting for 4 h. CONCLUSIONS： The optimal technology is reasonable and feasible, and it can be used for the extraction of Chinese medicinal materials from Compound sangju oral liquid.