Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects |
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Authors: | Pei-Hua Lu Jie Yang Chen Li Mu-Xin Wei Wei Shen Li-ping Shi Zhi-Yang Jiang Ning Zhou Guo-Qing Tao |
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Institution: | (1) Department of General Surgery, Wuxi People’s Hospital of Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, Jiangsu, China;(2) Department of Pharmacy, Wuxi People’s Hospital of Nanjing Medical University, No.299, Qingyang Road, Wuxi, 214023, Jiangsu, China;(3) Department of Gastroenterology, Xuzhou Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, No.80, Zhongshan South Road, Xuzhou, 221000, Jiangsu, China;(4) Department of Traditional Chinese Medicine, First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, Jiangsu, China |
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Abstract: | Published data on the association between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) gene rs889312 polymorphism
and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed.
Crude ORs with 95% CIs were used to assess the strength of association between them. A total of seven eligible articles including
26,015 cases and 33,962 controls based on the search criteria were involved in this meta-analysis. We observed that the MAP3K1
rs889312 polymorphism was significantly correlated with breast cancer risk from the fixed effects model when all studies were
pooled into the meta-analysis (the allele contrast model: OR 1.09, 95% CI 1.07–1.12; the homozygote codominant: OR 1.22, 95%
CI 1.15–1.29; the heterozygote codominant: OR 1.07, 95% CI 1.04–1.11; the dominant model: OR 1.10, 95% CI 1.06–1.13; the recessive
model: OR 1.18, 95% CI 1.12–1.25). No significant association was found in the BRCA1 mutation carriers in all genetic models.
When stratified by BRCA2 mutation carriers status, statistically significantly elevated risk was found in this meta-analysis
(C vs. A: OR 1.12, 95% CI 1.01–1.23; CC vs. AA: OR 1.35, 95% CI 1.06–1.71; the recessive model: OR 1.31, 95% CI 1.05–1.65).
There was no evidence for significant association between MAP3K1 rs889312 polymorphism and breast cancer risk in BRCA1 and
BRCA2 positive cohort for all comparison models. In conclusion, this meta-analysis suggests that the MAP3K1 rs889312 C allele
is a low-penetrant risk factor for developing breast cancer, and there is limited evidence to indicate that MAP3K1 rs889312
polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers. |
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