RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects |
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| Authors: | Haiming Sun Jing Bai Feng Chen Yan Jin Yang Yu Lianhong Jin Songbin Fu |
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| Institution: | (1) Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, 150081, China;(2) Key Laboratory of Medical Genetics (Harbin Medical University), Heilongjiang Higher Education Institutions, Harbin, China;(3) Department of Histology and Embryology, Harbin Medical University, Harbin, 150081, China; |
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| Abstract: | Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer,
but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was
performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant
decreased risk was found for the additive model (OR = 0.995, 95% CI = 0.991–0.998) and dominant model (OR = 0.994, 95% CI = 0.991–0.998).
In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977,
95% CI = 0.954–1.000 and dominant model: OR = 0.981, 95% CI = 0.963–1.000). In conclusion, this meta-analysis suggests that
the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer. |
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