Lack of an association between AURKA T91A polymorphisms and breast cancer: a meta-analysis involving 32,141 subjects |
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Authors: | Haiming Sun Jing Bai Feng Chen Yan Jin Yang Yu Songbin Fu |
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Institution: | (1) Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, 150081, China;(2) Key Laboratory of Medical Genetics (Harbin Medical University), Heilongjiang Higher Education Institutions, Harbin, 150081, China; |
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Abstract: | Several studies have investigated the associations between AURKA T91A polymorphism and the susceptibility to breast cancer,
but the results have been inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed.
A total of 11 case–control studies, including 14,361 cases and 17,780 controls, were selected. Crude odds ratios (ORs) with
95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, and
recessive model. When all the studies were pooled into the meta-analysis, there was no evidence showing a significant association
between AURKA T91A polymorphism and breast cancer risk (for additive model, OR = 0.839, 95% CI = 0.678–1.038; for dominant
model: OR = 0.890, 95% CI = 0.757–1.074; and for recessive model: OR = 0.987, 95% CI = 0.963–1.012). In the subgroup analysis
by ethnicity, significantly decreased risks were found for Asians (additive model, OR = 0.857, 95% CI = 0.742–0.991). When
stratified by study design, no significant association was found between the polymorphism and breast cancer risk. In conclusion,
this meta-analysis indicates that the AURKA T91A polymorphism is not a risk factor for developing breast cancer. |
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