Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice |
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Authors: | Mohanasundari M Sabesan M |
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Affiliation: | Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India. |
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Abstract: | The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced astrocyte activation in striatal area induced by MPTP. The results show that HPE has neuromodulating effect against MPTP induced Parkinson's disease in mice. |
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