Current standards of care for chemotherapy of optimally cytoreduced advanced epithelial ovarian cancer |
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Authors: | Maurie Markman |
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Affiliation: | Cancer Treatment Centers of America, Philadelphia, PA, United States |
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Abstract: | There has been limited change in evidence-based primary chemotherapeutic management of optimal residual advanced ovarian cancer for more than a decade. The backbone of therapy remains a platinum agent (generally carboplatin) and a taxane (generally paclitaxel). Phase 3 randomized trial data provide support for the use of weekly paclitaxel in this setting (compared to the traditional every 3-week schedule) and the addition of bevacizumab as a component of primary management. Recently available data provide increasingly solid support for a role of regional platinum administration in at least a subset of patients with optimal residual advanced ovarian cancer and an important retrospective analysis has suggested a novel biomarker that may predict for the utility (or lack thereof) of this method of drug delivery. |
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Keywords: | Ovarian cancer Chemotherapy Optimal residual disease |
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