终末期肾脏病患者血清脂联素水平及与炎症因子的相关性研究

目的检测终末期肾脏病（ESRD）患者血清脂联素（ADPN）、肿瘤坏死因子-α（TNF—α）、超敏C反应蛋白（hs—CRP）及肾功能水平，探讨ESRD患者血清ADPN水平的变化及与炎症因子的关系。方法选择ESRD患者60例，分为3组：肾衰非透析组（18例）、血液透析组（22例）和腹膜透析组（20例）。另设健康对照组（20例）。用ELISA方法检测血清ADPN、TNF—α和hs—CRP。比较各组间的差别。结果ESRD患者血清ADPN水平在肾衰非透析组（15．88±4．94）mg／L]、血液透析组（14．26±4．54）mg／L]和腹膜透析组（14．55±3．51）mg／L]均显著升高（与对照组（4．95±2．19）mg／L]相比，P〈0．01），但非透析和透析各组之间的差异无统计学意义（P〉0．05）。ESRD患者的血清TNF—α和hs—CRP水平在透析和非透析各组亦显著升高（与对照组相比，P〈0．01），并且在透析患者显著高于非透析患者（P〈0．01）。ESRD患者的血清ADPN水平与TNF—α呈正相关（r≥0．478，P〈0．01），与肾小球滤过率呈负相关（r≥-0．582，P〈0．01）。结论ESRD患者的血清ADPN水平明显升高，并与TNF—α、肾小球滤过率等因素有关。

Serum adiponectin levels and inflammatory markers in patients with end-stage renal disease

Objective To examine the levels of serum adipunectin (ADPN)in patients with end-stage renal disease (ESRD), and identify the relationship between serum ADPN and tumor necrosis factor (TNF)-α, high sensitivity C-reactive protein(hs-CRP) and renal function. Methods Sixty ESRD patients and twenty normal healthy persons were involved in this study. The patients were divided into three groups: patients with chronic renal failure (CRF, 18 cases), patients with hemodialysis (HD,22 cases) and patients with peritoneal dialysis (PD,20 cases). The levels of serum ADPN, TNF-α and hs-CRP were detected by means of ELISA. Differences in continuous variables be-tween the three groups were evaluated. Results The levels of serum ADPN, TNF-α and hs-CRP in CRF, HD and PD patients were signifi-cantly higher than those in control group ( P<0.01 ). Serum ADPN levels in ESRD patients were positive related to serum TNF-α( r≥0.478, P<0.01 ), and negative related to GFR ( r≥-0.582, P<0.01 ). Conclusion The level of serum ADPN was markedly in-creased in patients with ESRD, and correlated with serum TNF-α level and.renal function.