Prevention of infection during transrectal biopsy of prostate through double-glove technique.

Eighty male patients, most of whom had suspicious prostatic nodules on digital examination, were subjected to transrectal needle biopsy of the prostate. The biopsy needle was held between the gloved hand and an overlying sterile finger cot on the index finger. When the lesion was palpated, the needle was pushed through the finger cot and a tissue specimen obtained. All patients were treated orally with minocycline hydrochloride 100 mg. twice a day starting eight to twelve hours before biopsy and continuing at this dosage for five days after biopsy. Except for one episode of transitory hematuria, there were no reports of infection or complication, as manifested by fever, chills, or transrectal or transurethral bleeding.