| 复方银杏叶片的急性毒性实验研究 |
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| 引用本文： | 潘洪平,危华玲,陈英,钟正贤,陈学芬,李燕婧,路玫.复方银杏叶片的急性毒性实验研究[J].时珍国医国药,2007,18(6):1325-1325. |
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| 作者姓名： | 潘洪平 危华玲 陈英 钟正贤 陈学芬 李燕婧 路玫 |
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| 作者单位： | 1. 广西壮族自治区人民医院,广西,南宁,530021
2. 广西壮族自治区中医药研究所,广西,南宁,530022 |
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| 基金项目： | 广西壮族自治区科学基金项目(No.0342003-1) |
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| 摘 要： | 目的观察复方银杏叶片的急性毒性反应。方法复方银杏叶片以最大浓度及最大给药体积的药液灌胃给药,3次/d。连续观察7 d,记录小鼠毒副反应情况。结果观察7 d后,全部动物健存,小鼠体重平均增长24.82%,未见任何毒性反应。计算得葛根素最大给药量为3339.6 mg/kg体重,相当于成人日用量的2360.1倍。结论提示复方银杏叶片毒性较小。
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| 关 键 词： | 复方银杏叶片 小鼠 急性毒性 |
| 文章编号： | 1008-0805（2007）06-1325-01 |
| 收稿时间： | 2006-11-09 |
| 修稿时间： | 2006-11-092007-03-09 |
Experimental Study on Acute Toxicity of Compound Ginkgo biloba Tablets in Mice |
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| PAN Hong-ping,WEI Hua-ling,CHEN Ying,ZHONG Zheng-xian,CHEN Xue-fen,LI Yan-jing,LU Mei.Experimental Study on Acute Toxicity of Compound Ginkgo biloba Tablets in Mice[J].Lishizhen Medicine and Materia Medica Research,2007,18(6):1325-1325. |
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| Authors: | PAN Hong-ping WEI Hua-ling CHEN Ying ZHONG Zheng-xian CHEN Xue-fen LI Yan-jing LU Mei |
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| Abstract: | Objective To study the toxic reaction on Compound Ginkgo biloba Tablets in mice.Methods The maximum administration dosage of Compound Ginkgo biloba Tablets were determined by ig administration in mice,three times a day.Its acute toxic reactions were observed for 7 days.Results All mice were survive,and no toxic reaction was shown during the observed period .The average rate of its increasing weight was 24.82 percent.The maximum administration dosage was 3 339.6 mg of puerarin given to mice per kilogram,equivalent to men's daily administration dosage by 2360.1 times.Conclusion Compound Ginkgo biloba Tablets is safe for oral administration. |
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| Keywords: | Compound Ginkgo biloba Tablets Mice Acute toxicity |
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