Behavioral effects of severe and moderate early malnutrition |
| |
| Authors: | C Wolf C R Almli S Finger S Ryan P J Morgane |
| |
| Affiliation: | 1. Department of Neurosurgery, King’s College Hospital NHS Foundation Trust, London, United Kingdom;2. Department of Clinical Neuropathology, King’s College Hospital NHS Foundation Trust, London, United Kingdom;1. The University of Alabama at Birmingham (UAB) Department of Nutrition Sciences, United States;2. Florida International University College of Arts Sciences and Education, United States;3. UAB Department of Epidemiology, United States;1. Brain Health Department, Nestlé Institute of Health Sciences, Société des Produits Nestlé SA, Vers-Chez-les-Blanc, Lausanne, Switzerland;2. Applied Data Analytics Group, Nestlé Institute of Health Sciences, Société des Produits Nestlé SA, Vers-Chez-les-Blanc, Lausanne, Switzerland;3. Nutrition Science Group, Nestlé Institute of Health Sciences, Société des Produits Nestlé SA, Vers-Chez-les-Blanc, Lausanne, Switzerland;4. Advanced Baby Imaging Lab, Rhode Island Hospital, Providence, RI, USA;5. Department of Radiology, Warren Alpert Medical School at Brown University, Providence, RI, USA;6. Spinn Neuroscience, Seattle, WA, USA |
| |
| Abstract: | Rats with a history of prenatal and early postnatal undernutrition (6 or 8% casein diets) were "nutritionally rehabilitated" at weaning, and were compared to well-fed animals (25% casein) at maturity. The severely-malnourished (6%) animals were hyperactive in the open field and when tested in a stabilimeter. They also appeared to be highly active during the early trials in 8-arm radial maze testing where they made more arm entries and re-entry errors than the well-fed rats. In terms of trials to criterion, however, their scores on the radial maze and on a spatial alternation task fell within normal limits. The moderately-malnourished (8%) rats tended to perform at control levels on the learning measures, but these rats were not as active as the 6% rats on the measures of activity. Brain size and weight differences among the three groups of rats also are presented and discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
