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| 2种新型基因工程长效人胰岛素类似物 | |
| 引用本文： | 高剑坤,蔡绍皙,范开,龙波. 2种新型基因工程长效人胰岛素类似物[J]. 中国新药与临床杂志, 2007, 26(7): 548-552 |
| 作者姓名： | 高剑坤 蔡绍皙 范开 龙波 |
| 作者单位： | 1. 重庆大学生物工程学院,重庆,400044 2. 重庆工学院,重庆,400050 3. 绵阳市四零四医院,四川绵阳,621000 |
| 摘 要： | 甘精胰岛素和地特胰岛素是2种新型的人胰岛素类似物。虽然他们都通过基因工程的方法生产,药效能持续24h,无明显的波峰和波谷,是真正意义上的基础胰岛素,但是这2种长效胰岛素的分子结构、长效机制、生产工艺各不相同,在临床使用上也有各自的利弊。 |
| 关 键 词： | 甘精胰岛素 地特胰岛素 糖尿病 |
| 文章编号： | 1007-7669（2007）07-0548-05 |
| 收稿时间： | 2006-09-14 |
| 修稿时间： | 2006-09-142007-05-15 |
Two novel long acting human insulin analogs produced by genetic engineering |
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| GAO Jian-kun,CAI Shao-xi,FAN Kai,LONG Bo. Two novel long acting human insulin analogs produced by genetic engineering[J]. Chinese Journal of New Drugs and Clinical Remedies, 2007, 26(7): 548-552 | |
| Authors: | GAO Jian-kun CAI Shao-xi FAN Kai LONG Bo |
| Affiliation: | 1. Bioengineering College of Chongqing University, CHONGQING 400044, China; 2. Chongqing Institute of Technology, CHONGQING 400050, China ; 3. Mianyang Municipal 404th Hospital, Mianyang SICHUAN 621000, China |
| Abstract: | Insulin glargine and insulin detemir are both of human insulin analogs, produced through genetic research engineering. They are both basal insulins; because of they can remaining active for a full 24 hours with essentially no peaks or valleys, but having different molecular structure, long acting mechanisms, artworks and different clinical effects. |
| Keywords: | insulin glargine insulin detemir diabetes mellitus |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |