| 高效液相色谱法测定门冬氨酸洛美沙星氯化钠注射液的含量 |
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| 引用本文： | 赵卉,杨菲,樊红梅,吴沂.高效液相色谱法测定门冬氨酸洛美沙星氯化钠注射液的含量[J].中国药业,2012,21(14):58-59. |
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| 作者姓名： | 赵卉 杨菲 樊红梅 吴沂 |
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| 作者单位： | 陕西金裕制药股份有限公司,陕西,西安,710075 |
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| 摘 要： | 目的建立测定门冬氨酸洛美沙星含量的高效液相色谱法。方法采用Agilent TC-C18柱(250 mm×4.6 mm,5μm),以0.05 mol/L枸橼酸溶液-乙腈(82∶18,用三乙胺调pH至4.0)为流动相,流速1.0 mL/min,检测波长为288 nm。结果洛美沙星质量浓度在13.59～67.93μg/mL(r=1.000)范围内与峰面积呈良好的线性关系,平均回收率为100.04%,RSD=1.53%(n=9)。结论该方法准确度高,灵敏度好,专属性强,适合于门冬氨酸洛美沙星的含量测定。
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| 关 键 词： | 高效液相色谱法 门冬氨酸洛美沙星 含量测定 |
Determination of Lomefloxacin Aspartate and Sodium Chloride Injection by HPLC |
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| Zhao Hui
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Yang Fei
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Fan Hongmei
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Wu Yi.Determination of Lomefloxacin Aspartate and Sodium Chloride Injection by HPLC[J].China Pharmaceuticals,2012,21(14):58-59. |
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| Authors: | Zhao Hui Yang Fei Fan Hongmei Wu Yi |
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| Institution: | ( Shaanxi Jinyu pharmaceutical Co. , Ltd. , Xi＇ an, Shaanxi, China 710075) |
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| Abstract: | Objective To establish a HPLC method for the determination of lomefloxacin aspartate. Methods The analysis was performed on Agilent TC-C18 column（250 mm ×4.6 mm,5 um）. The mobile phase was composed of citric acid（0.05 mol/L）- methyl cyanides （82 ： 18）（adjusted to pH 4.0 with Triethylamine）at a flow rate of 1.0 mL/min. The detection wavelength was 288 nm. Results The linear ranges of lomefloxacin aspartate was 13.59 - 67.93 ug/mL, r = 1. 000. The average recovery was 100. 04% , RSD = 1.53% （ n = 9）. Conclusion This method is accurate, convenient and specific. It can be used for the determination of lomefloxacin aspartate and sodium chloride injection. |
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| Keywords: | HPLC lomefloxacin aspartate determination |
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