3种微生态制剂对抗菌药物的敏感性检测

目的 检测常用微生态制荆双歧杆菌四联活菌片、地衣芽孢杆菌活菌胶囊、酪酸梭菌活菌片对16种抗菌药物的敏感性.方法 从3种微生态制剂中培养并分离供试菌,用微生物鉴定分析仪和药敏纸片进行药物敏感性检测.结果 双歧杆菌四联活菌片对抗菌药物均敏感;地衣芽孢杆菌活菌胶囊对青霉素类、头孢菌素类、红霉素、克林霉素有不同程度的耐药,对氨基苷类、喹诺酮类等抗菌药物敏感;酪酸梭菌活菌片对头孢菌素类、氨基苷类、复方新诺明耐药,对青霉素类、红霉素、克林霉素、喹诺酮类等抗菌药物敏感.结论 根据药物敏感性试验,地衣芽孢杆菌活菌胶囊、酪酸梭菌活菌片可以与耐药的抗菌药物联用,双歧杆菌四联活菌片与抗菌药物有配伍禁忌,避免联用,必须联用时应错开服用时间.

Susceptibility Testing of Three Kinds of Microecological Preparation to Antimicrobial Agents

Objective To detect the susceptibility of frequently-used microecological preparations Tetralogy of Viable Bifidobacterium Tablet,Bacillus Licheniformis Living Bacterial Capsule and Clostridium Butyricum Living Bacterial Tablet to 16 kinds of antimicrobial agents.Methods To culture and isolate the tested bacteria from these three kinds of probiotics,and the drug sensitivity testing was performed by using the microorganism analyzer and the drug sensitive slips.Results Tetralogy of Viable Bifidobacterium Tablet was sensitive to all the antimicrobial agents,Bacillus Licheniformis Living Bacterial Capsule was resistant to penicillins,cephalosporins,erythromycin and clindamycin with different degrees,but sensitive to aminoglycosides,and quinolones.Clostridium Butyricum Living Bacterial Tablet was resistant to cephalosporins,aminoglycosides and cotrimoxazole,but sensitive to penicillin,erythromycin,clindamycin and quinolones.Conclusion According to drug sensitivity test,Bacillus Licheniformis Living Bacterial Capsule and Clostridium Butyricum Living Bacterial Tablet can be used in combination with the resistant antimicrobial agents.But Tetralogy of Viable Bifidobacterium Tablet has the incompatibility with antibacterial agents and should be avoid the combination use with them,if must together using,the taking time should be stagger.