加替沙星治疗细菌性下呼吸道感染113例

目的观察加替沙星治疗细菌性下呼吸道感染的临床疗效与安全性。方法选取下呼吸道细菌感染患者226例,随机分为两组,治疗组给予加替沙星注射液200 mg,对照组给予左氧氟沙星注射液200 mg,均静脉滴注,每天2次,疗程7～10 d。结果治疗组和对照组的痊愈率分别为80.53%和72.57%,有效率分别为91.15%和83.19%,细菌清除率分别为85.84%和78.76%,两组间比较,差异均有统计学意义(P<0.05);不良反应发生率分别为3.54%和5.31%,两组比较,差异无统计学意义(P>0.05)。结论加替沙星治疗常见致病菌引起的下呼吸道感染,疗效确切、使用安全,值得临床推广。

Gatifloxacin in Treating 113 Cases of Bacterial Lower Respiratory Infections

Objective To investigate the clinical efficacy and safety of gatifloxacin in treating bacterial lower respiratory iniections. Methods Two hundred and twenty-six cases of bacterial lower respiratory infections were selected and divided into two groups. The treatment group was given gatifloxacin 200 mg by intravenous drip, twice daily, for 7- 10 d. The control group received levofloxacin 200 mg by intravenous drip, twice daily, for 7- 10 d. Results The cure rates of the treatment group and the control group were 80. 53% and 72.57%, respectively. The effective rates were 91.15% and 83.19%, respectively. The clearance rates of bacteria were 85.84% and 78.76%, respectively. The two groups showed statistical difference in these three parameters （P 〈 0. 05）. The adverse reaction rates were 3.54% and 5.31%, respectively, showing no statistical difference between 2 groups （P 〉0. 05）. Conclusion Gatifloxacin shows good efficacy and safety for the treatment of lower respiratory infections caused by common pathogens. Thus, it is worthy of clinical popularization.