Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats |
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| Authors: | José Monroy-Ruiz María-Ángeles Sevilla Rosalía Carrón María-José Montero |
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| Affiliation: | 1. Departamento de Salud, Universidad Iberoamericana, Prolongación Paseo de la Reforma 880, Ciudad de México, Mexico;2. Departamento de Fisiología y Farmacología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain;1. Department of Higher Education Sport, Loughborough College, United Kingdom;2. Department of Sport, Health and Exercise Science, University of Hull, United Kingdom;3. School of Life Sciences, University of Westminster, United Kingdom;4. School of Health Sciences, Birmingham City University, United Kingdom;5. Sport Nutrition and Performance Research Group, Department of Sport and Physical Activity, Edge Hill University, United Kingdom;6. Department of Sport and Movement Studies, University of Johannesburg, South Africa;1. Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih 43500, Selangor Darul Ehsan, Malaysia;2. School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih 43500, Selangor Darul Ehsan, Malaysia;3. Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia;1. School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1;2. Ontario Ministry of Agriculture, Food and Rural Affairs, 1 Stone Road West, Guelph, Ontario, Canada N1G 4Y1 |
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| Abstract: | The aim of this study was to investigate the effects of astaxanthin-enriched diet on blood pressure, cardiac hypertrophy, both vascular structure and function and superoxide ( O2?) production in spontaneously hypertensive rats (SHR).Twelve-week-old SHR were treated for 8 weeks with an astaxanthin-enriched diet (75 or 200 mg/kg body weight per day). Systolic blood pressure was monitorized periodically during the study by the tail cuff method. At the end of the study animals were sacrificed and heart, kidneys and aorta were removed. Left ventricular weight/body weight ratio was used as left ventricular hypertrophy index (LVH). Vascular function and structure were studied in conductance (aortic rings) and resistance (renal vascular bed) arteries. Also O2? production was evaluated by lucigenin-enhanced chemiluminescence.Systolic blood pressure was lower in astaxanthin-treated groups than the control group from the first week of treatment, and LVH was significantly reduced. Astaxanthin improved endothelial function on resistance arteries, but had no effect on aorta. These effects were accompanied by a decrease in oxidative stress and improvements in NO bioavailability. Taken together, these results show that diet supplemented with astaxanthin has beneficial effects on hypertension, by decreasing blood pressure values, improving cardiovascular remodeling and oxidative stress. |
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