Intercontinental spread from Israel to Colombia of a KPC-3-producing Klebsiella pneumoniae strain |
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Authors: | J.A. Lopez A. Correa S. Navon-Venezia A.L. Correa J.A. Torres D.F. Briceño M.C. Montealegre J.P. Quinn Y. Carmeli M.V. Villegasz |
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Affiliation: | 1. Hospital Pablo Tobón Uribe, Medellín, Colombia;2. International Centre for Medical Research & Training (CIDEIM), Cali, Colombia;3. Division of Epidemiology and the Laboratory for Molecular Epidemiology and Antibiotic Research, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel;4. Pfizer Global Research and Development, New London, CT, USA |
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Abstract: | In 2008, an increase in the prevalence of carbapenem-resistant Klebsiella pneumoniae was noted in a 286-bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR-restriction fragment length polymorphism analysis and sequencing revealed blaKPC-3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase-3-producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase-producing pathogens. |
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Keywords: | Colombia dissemination Israel KPC-3 |
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