| 基于胰腺纤维化微环境探讨中医药防治慢性胰腺炎的机制 |
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| 引用本文： | 彭青侠,许小凡,段丽芳,张红. 基于胰腺纤维化微环境探讨中医药防治慢性胰腺炎的机制[J]. 中医药导报, 2021, 27(3): 159-163 |
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| 作者姓名： | 彭青侠 许小凡 段丽芳 张红 |
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| 作者单位： | 陕西中医药大学基础医学院,陕西西安712046;陕西中医药大学医学科研实验中心,陕西西安712046;陕西中医药大学基础医学院,陕西西安712046;陕西中医药大学医学科研实验中心,陕西西安712046 |
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| 基金项目： | 国家自然科学基金项目(81673816);胰、肝疾病的分子机制及中医药防治创新团队(2019-YL14);陕西省自然科学基础研究一般项目(2018JM7085)。 |
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| 摘 要： | 从胰腺纤维化的微环境出发,综述了多种细胞在慢性胰腺炎发病中的作用,以及中医药防治慢性胰腺炎的相关机制.中医药可通过调节细胞外基质的过度产生和降解,抑制胰腺星状细胞的活化、腺泡细胞的凋亡、炎症细胞的浸润和炎性因子的释放来减缓胰腺纤维化,从而达到防治慢性胰腺炎的目的,为慢性胰腺炎的临床治疗提供参考.
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| 关 键 词： | 慢性胰腺炎 胰腺纤维化 微环境 中医药 胰腺星状细胞 胰腺腺泡细胞 炎症细胞 机制 |
Discussion on the Mechanism of Prevention and Treatment of Chronic Pancreatitis with Traditional Chinese Medicine Based on Pancreatic Fibrosis Microenvironment |
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| PENG Qing-xia,XU Xiao-fan,DUAN Li-fang,ZHANG Hong. Discussion on the Mechanism of Prevention and Treatment of Chronic Pancreatitis with Traditional Chinese Medicine Based on Pancreatic Fibrosis Microenvironment[J]. GUIDING JOURNAL OF TCM, 2021, 27(3): 159-163 |
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| Authors: | PENG Qing-xia XU Xiao-fan DUAN Li-fang ZHANG Hong |
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| Affiliation: | (School of Basic Medicine,Shaanxi University of Chinese Medicine,Xi'an Shaanxi 712046,China;Medical Research Experimental Center,Shaanxi University of Chinese Medicine,Xi'an Shaanxi 712046,China) |
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| Abstract: | Based on the microenvironment of pancreatic fibrosis,this paper summarizes the role of various cells in the pathogenesis of chronic pancreatitis and the related mechanism of traditional Chinese medicine in preventing and treating chronic pancreatitis.Traditional Chinese medicine can slow down pancreatic fibrosis by regulating the excessive production and degradation of extracellular matrix,inhibiting the activation of pancreatic stellate cells,apoptosis of acinar cells,infiltration of inflammatory cells and release of inflammatory factors,thus achieving the purpose of preventing and treating chronic pancreatitis and providing reference for clinical treatment of chronic pancreatitis. |
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| Keywords: | chronic pancreatitis pancreatic fibrosis microenvironment traditional Chinese medicine pancreatic stellate cells acinar cells inflammatory cells mechanism |
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