电压门控钙离子通道药物研究进展

电压门控钙离子通道家族（VGCC）是细胞表面一类重要的信号转换器，它能够将膜电势转变成局部胞内钙离子瞬时变化，从而启动许多重要的生理活动，例如肌肉收缩、激素分泌、神经传递和基因表达。VGCC表达和功能的异常与高血压、心绞痛、心律失常、疼痛、癫痫和帕金森病等疾病的发生有很大关系。近年来，以VGCC为靶点的药物在临床上表现出良好的治疗效果和较小的不良反应，具有较好的应用前景。综述VGCC的结构、功能以及相关药物研究进展，以期为与VGCC相关的药物开发提供参考。

Research Progress of Voltage Gated Calcium Ion Channel Drugs

Voltage-gated calcium channels(VGCC)are an important type of signal transverter on the cell membrane.It can transform membrane potential into local intracellular calcium ion instantaneous changes,thereby initiating many important physiological activities such as muscle contraction,hormone secretion,nerve transmission and gene expression.Abnormal expression and dysfunction of VGCC are associated with the occurrence of diseases like hypertension,angina pectoris,arrhythmia,pain,epilepsy and Parkinson’s disease.In recent years,drugs targeting VGCC have shown good therapeutic effects and minor adverse reactions,with good application prospects.The structure and function of VGCC and the research progress of related drugs are reviewed in order to provide reference for the development of drugs related to VGCC.