参与P-gp膜定位和功能调控的相关蛋白研究进展

P-糖蛋白（P-gp）作为ABC转运体家族的成员之一，只有定位在细胞膜上才具有外排药物及毒物的功能。P-gp在细胞膜上的定位和功能受到多种机制调控。P-gp通过ERM（ezrin/radixin/moesin）蛋白家族锚定在膜上，其中脂筏区域在P-gp转运通道的形成中起重要作用，微囊蛋白-1（Cav-1）定位于小窝，作为脂筏上一种重要蛋白成分，与P-gp结合调节其结构和功能。综述参与P-gp膜定位和功能调控的相关蛋白研究进展，以期为P-gp在膜上的功能和表达研究提供新的方向。

Research Progress of Proteins Involved in the Location and Function Regulation of P-gp on Plasma Membrane

P-glycoprotein(P-gp),as a member of the ABC transporter family,possesses the function of pumping drugs and toxicity out of cells when located on the plasma membrane.This process is regulated by various factors.P-gp is anchored to the cell plasma membrane through the combination effect of the ERM(ezrin/radixin/moesin)protein family.The lipid raft region plays an important role in the formulation of the P-gp transport function on plasma membrane.Caveolin-1(Cav-1)is located on the caveolae as an important function protein on lipid raft,which combines with P-gp to regulate its structure and function.The article reviews the research progress of proteins involved in the location and function regulation of P-gp on plasma membrane,so as to provide a new direction for the research on the function and expression of P-gp on plasma membrane.